ABSTRACT
Background@#Even though there are lots of good treatment methods, medicines and biomaterials in use for broken bones due to international scientific researches on the ossifying process and its mechanism, which are being studied on high level and bringing new solutions, there is still a lack of inexpensive but good quality medicines that have low side effects and specifically targets on the enhancement of osteoblasts. </br> Despite of the level of fractures, therapeutic effects and multiple bone fractures, only certain drugs and medicines such as solution of baragshun and rhodiola, kitchen grime, chili-san and calcium are used for ossifying broken bones and fractures in Mongolia which indicates that there are certain needs of new medicine and drugs.@*Methods@#Patients who had a intramedullary osteosynthesis surgery to deal with tibia bone fractures were divided randomly into two groups; 1.5 gram Osteo calcium-5 is given to the experimental group while the comparison group got Calcium nycomed D3 for 60 days. </br> X-ray pictures were taken at the 56th and the 84th day after the fractures were diagnosed and analyzed by Warden method (et al 2009). TGF-β1, BMP-2 cytokines and alkaline phosphatase were evaluated on the 3rd, the 14th and the 42nd day of the study.@*Results@#Compared to the comparison group, which used Calcium Nycomed D3, the experimental group patient, who used osteocalcium-5, had a similar TGF-β1 level at the 3rd day (p=1.0), a higher level at the 14th day (p=0.0001) and a lower level at the 42nd day (p=0.015).Analyzing fracture ossifying process with the Warden et al method shows that the ossifying points of the Osteo calcium-5 group were 1.73 on 53rd day and 2.79 on 84th day while the ossifying points of the comparison group was 1.41 on 56th day and 2.35 on 84th day (p=0.034),( p=0.04).@*Conclusions@#According to the study, Osteo calcium-5 has proven to have better effects on decreasing inflammation process and accelerating bone ossify, cartilage and bone formation with the analysis of cytokine in serum and structure.
ABSTRACT
INTRODUCTION: Nowadays, the population of noncommunicable sickness is growing rapidly changing lifestyle is one example of this is the widening of accidents-related bone fractures.The National Center for Trauma Treatment of inpatient hospital from a total fractures 10260 or 30.8%, of which 6777 or 66.05% of the marrow bone fractures as well as drugs used in refractive rarely occupied. PURPOSE: To consider a result of the use of Osteocalcium 5 medical preparation for patients who were diagnosed diaphyseal fracture of the tibia and treated by Intramedullar Osteosyntesis (internal fixation)OBJECTIVES:1. To establish process of fractured bone remodeling to original bone contour by TGF-b1 cytokine dynamics in serum2. To establish process of fractured bone remodeling to original bone contour by alkaline phosphatase dynamics in serumMATERIALS AND METHODS: Within the framework of the survey 28 patients of the “Bone, joint and limb section” Section of the National Institute of Traumatology, aged between 25-60 years, were involved in the present survey. Survey participants were classified in 2 groups according to “Krischner wire” position and their Xray’s images. An accordance to the methodology of James Balch and Mark Stengller (2011) daily dosage of the Osteocalcium 5 preparation for test and comparing patients was determined as following introduced: for test group-twice a day before meal 1.5 grams, for comparing group–Calcium D3Nycomed preparation three times a day during 60 days. Transforming growth factor-beta 1(TGFb1) and Alkaline phosphatase was equal of 3, 14, 42 fraction days.RESULT: The present diagram shows that according to the curve TGF-b1 the bone excrescence performance of the Osteocalcium 5 preparation (0.0001) is statically increasing at 14 days and after 42 days it is statically decreasing and the calculated discrepancy (p<0.015) reveals and proofs the impact of its bone excrescence. Alkaline phosphatase in serum 14 days after the fracture Osteocalcium 5 pills used in chapter Nycomed Calcium D3 drank chapters (116,06±35U/L) compared to a statistical difference (p<0.044).CONCLUSION: Preparations Ostyeokalitsi 5 osteoblast chondrocyte cell activity and enable them synthesized by the cells in the TGF-B1 osteoblast line Alkaline phosphatase synthesized in increased serum concentrations of the bone heal affect signaling molecules involved are determined that quickens recovery.